TEAM - Current and Past Graduates
Canadian Pacific Chair in Biotechnology
BSc (Biochemistry) - McGill University
PhD (Biochemistry) - McGill University
- Drug resistance in cancer and malaria
- Protein protein interactions
- Novel therapeutic approaches
Project: Biochemical characterization of PfCRT: Normal functions and substrate interactions in P. falciparum and heterologous expression system.
Project: Molecular Mechanisms of ABCB1-mediated collateral sensitivity in tumour breast cancer cells.
Project: Characterization of P. falciparum ABCG Transporter Functions and Subcellular Trafficking
Project: Construction of PfABCG Chimeras and expression in a heterologous system
Project: Heterologous Expression of Pfabcg in mammalian cells and sub cellular localization.
Project: Collateral sensitivity of ABCB1-positive tumour cells to Tamoxifen.
Project: Eryptosis as novel approach to Plasmodium falciparum drug targeting
Project: Role of PfMDR1 and PfCRT in drug transport. Characterization of PfABCG transporter.
Project: MK571 drug analogues and their effects on cells expressing ABCC1-5
Project: The effects of sorcin protein expression on the collateral sensitivity of multi-drug resistant tumour cells.
Project: Identification of ABCC1 Linker Domain Binding Proteins
Project: Study of ABCB1 and ABCC1 Mediated Collateral Sensitivity
Project: Identification and Characterization of ABCG2 in Human Erythrocytes as mainly Homo-dimer and Demonstration of ABCC2 Binding to LTC4.
Project: Mapping ABCC1 Binding Domains to Drugs and Endogenous Normal Ligands AND The Mechanism of Collateral Sensitivity
Project: Synthesis of Photo-reactive Drugs and Characterization Their Binding to ABCC1 in Drug Resistant Tumour Cells
Project: Demonstration and Characterization of ABCC1 Interactions with Quinoline Based Drugs
Project: Mechanism of ABCB1 (P-glycoprotein) Mediated Collateral Sensitivity in Drug Resistant Cells.
Project: Cloning and Characterization of the Proteosome S4 ATPase from P. falciparum.
Project: Study of Detergent ABC Transporters Interactions
Project: Isolation and Characterization of Actinomycin D Resistant P. falciparum.
Project: Characterize Iveramectin Binding to P-glycoprotein in Multi-drug Resistant Cells and Other Reversing agents.
Project: Identification and Characterization of Annexin I as Differentially Expressed Protein in Drug Resistant Cells.
Project: Synthesis of Photo-reactive Drugs and Characterizing their Binding to P-glycoprotein in Drug Resistant Cells
Project: Construction and Expression of Single Chain Monoclonal Antibody to Vimentin
Project: Isolation and Characterization of Drug Resistant Plasmodium falciparum