Peer-reviewed Publications

Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum. Fallatah O, Georges E. Int J Antimicrob Agents. 2017 Nov;50(5):673-677.

Sequences in Linker-1 domain of the multidrug resistance associated protein (MRP1 or ABCC1) bind to tubulin and their binding is modulated by phosphorylation. Ambadipudi R, Georges E. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1001-1006.

3-Iodo-4-aminoquinoline derivative sensitises resistant strains of Plasmodium falciparum to chloroquine. Edaye S, Tazoo D, Bohle DS, Georges E. Int J Antimicrob Agents. 2016 Jun;47(6):482-5.

3-Halo Chloroquine Derivatives Overcome Plasmodium falciparum Chloroquine Resistance Transporter-Mediated Drug Resistance in P. falciparum. Edaye S, Tazoo D, Bohle DS, Georges E. Antimicrob Agents Chemother. 2015 Dec;59(12):7891-3.
Characterization of native PfABCG protein in Plasmodium falciparum. Edaye S, Georges E. Biochem Pharmacol. 2015 Sep 15;97(2):137-46.

A 2-amino quinoline, 5-(3-(2-(7-chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid, interacts with PfMDR1 and inhibits its drug transport in Plasmodium falciparum. Edaye S, Reiling SJ, Leimanis ML, Wunderlich J, Rohrbach P, Georges E. Mol Biochem Parasitol. 2014 Jun;195(1):34-42.

Human ABCC1 Interacts and Colocalizes with ATP Synthase α, Revealed by Interactive Proteomics Analysis. Yang Y, Li Z, Mo W, Ambadipudi R, Arnold RJ, Hrncirova P, Novotny MV, Georges E, Zhang JT. J Proteome Res. 2012 Feb 3;11(2):1364-72.

Photoaffinity labeling of the multidrug resistance protein 2 (ABCC2/cMOAT) with a photoreactive analog of LTC(4). Leimanis ML, Karwatsky J, Georges E.  Int J Biochem Mol Biol. 2011;2(1):39-46.

Mutation of cysteine 21 inhibits nucleophosmin/B23 oligomerization and chaperone activity. Prinos P, Lacoste MC, Wong J, Bonneau AM, Georges E.  Int J Biochem Mol Biol. 2011;2(1):24-30.

RNAi-mediated knockdown of α-enolase increases the sensitivity of tumor cells to antitubulin chemotherapeutics. Georges E, Bonneau AM, Prinos P.  Int J Biochem Mol Biol. 2011;2(4):303-8. 

P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil. Laberge RM, Ambadipudi R, Georges E.  Arch Biochem Biophys. 2009 Nov;491(1-2):53-60.

Autofluorescence of condensed heme aggregates in malaria pigment and its synthetic equivalent hematin anhydride (beta-hematin). Bellemare MJ, Bohle DS, Brosseau CN, Georges E, Godbout M, Kelly J, Leimanis ML, Leonelli R, Olivier M, Smilkstein M.  J Phys Chem B. 2009 Jun 18;113(24):8391-401.

Sensitive detection of malaria infection by third harmonic generation imaging. Bélisle JM, Costantino S, Leimanis ML, Bellemare MJ, Bohle DS, Georges E, Wiseman PW.  Biophys J. 2008 Feb 15;94(4):L26-8.

The P-glycoprotein (ABCB1) linker domain encodes high-affinity binding sequences to alpha- and beta-tubulins.  Georges E.  Biochemistry. 2007 Jun 26;46(25):7337-42.

ABCG2 membrane transporter in mature human erythrocytes is exclusively homodimer. Leimanis ML, Georges E.  Biochem Biophys Res Commun. 2007 Mar 9;354(2):345-50.

Modulation of GSH levels in ABCC1 expressing tumor cells triggers apoptosis through oxidative stress. Laberge RM, Karwatsky J, Lincoln MC, Leimanis ML, Georges E.  Biochem Pharmacol. 2007 Jun 1;73(11):1727-37.

Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda. Fotie J, Bohle DS, Leimanis ML, Georges E, Rukunga G, Nkengfack AE.  J Nat Prod. 2006 Jan;69(1):62-7.

The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. Karwatsky J, Leimanis M, Cai J, Gros P, Georges E.  Biochemistry. 2005 Jan 11;44(1):340-51.

Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Alqawi O, Bates S, Georges E.  Biochem J. 2004 Sep 1;382(Pt 2):711-6.

Drug binding domains of MRP1 (ABCC1) as revealed by photoaffinity labeling. Karwatsky JM, Georges E.  Curr Med Chem Anticancer Agents. 2004 Jan;4(1):19-30. Review.

Annexin-I expression modulates drug resistance in tumor cells. Wang Y, Serfass L, Roy MO, Wong J, Bonneau AM, Georges E.  Biochem Biophys Res Commun. 2004 Feb 6;314(2):565-70.

A mechanism for P-glycoprotein-mediated apoptosis as revealed by verapamil hypersensitivity. Karwatsky J, Lincoln MC, Georges E.  Biochemistry. 2003 Oct 28;42(42):12163-73.

Photoaffinity labeling under non-energized conditions of a specific drug-binding site of the ABC multidrug transporter LmrA from Lactococcus lactis. Alqawi O, Poelarends G, Konings WN, Georges E.  Biochem Biophys Res Commun. 2003 Nov 21;311(3):696-701.

The multidrug resistance protein ABCC1 drug-binding domains show selective sensitivity to mild detergents. Alqawi O, Georges E.  Biochem Biophys Res Commun. 2003 Apr 18;303(4):1135-41.

Binding of a photoaffinity analogue of glutathione to MRP1 (ABCC1) within two cytoplasmic regions (L0 and L1) as well as transmembrane domains 10-11 and 16-17.  Karwatsky J, Daoud R, Cai J, Gros P, Georges E.  Biochemistry. 2003 Mar 25;42(11):3286-94.

Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6).  Cai J, Daoud R, Alqawi O, Georges E, Pelletier J, Gros P.  Biochemistry. 2002 Jun 25;41(25):8058-67.

Functional expression of multidrug resistance protein 1 in Pichia pastoris. Cai J, Daoud R, Georges E, Gros P.  Biochemistry. 2001 Jul 27;40(28):8307-16.

Major photoaffinity drug binding sites in multidrug resistance protein 1 (MRP1) are within transmembrane domains 10-11 and 16-17. Daoud R, Julien M, Gros P, Georges E.  J Biol Chem. 2001 Apr 13;276(15):12324-30. Epub 2001 Jan 4.

Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1). Daoud R, Kast C, Gros P, Georges E.  Biochemistry. 2000 Dec 19;39(50):15344-52.

The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites. Daoud R, Desneves J, Deady LW, Tilley L, Scheper RJ, Gros P, Georges E.  Biochemistry. 2000 May 23;39(20):6094-102.

Reversal of MRP-mediated doxorubicin resistance with quinoline-based drugs. Vezmar M, Georges E.  Biochem Pharmacol. 2000 May 15;59(10):1245-52.

Pleiotropic resistance to diverse antimalarials in actinomycin D-resistant Plasmodium falciparum. Abrahem A, Certad G, Pan X, Georges E.  Biochem Pharmacol. 2000 May 1;59(9):1123-32.

Cloning and partial characterization of the proteasome S4 ATPase from Plasmodium falciparum. Certad G, Abrahem A, Georges E.  Exp Parasitol. 1999 Nov; 93(3):123-31.

Direct binding of chloroquine to the multidrug resistance protein (MRP): possible role for MRP in chloroquine drug transport and resistance in tumor cells.  Vezmar M, Georges E.  Biochem Pharmacol. 1998 Sep 15;56(6):733-42.

Overexpression of a 40-kDa protein in human multidrug resistant cells. Wang Y, Pan XQ, Lheureux F, Georges E. Biochem Biophys Res Commun. 1997 Jul 18;236(2):483-8.

The quinoline-based drug, N-[4-[1-hydroxy-2-(dibutylamino)ethyl] quinolin-8-yl]-4-azidosalicylamide, photoaffinity labels the multidrug resistance protein (MRP) at a biologically relevant site. Vezmar M, Deady LW, Tilley L, Georges E.  Biochem Biophys Res Commun. 1997 Dec 8;241(1):104-11.

Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Pouliot JF, L'Heureux F, Liu Z, Prichard RK, Georges E.  Biochem Pharmacol. 1997 Jan 10;53(1):17-25.

BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells. Liu Z, Lheureux F, Pouliot JF, Heckel A, Bamberger U, Georges E.  Mol Pharmacol. 1996 Sep;50(3):482-92.

p-Azidosalicyl-5-amino-6-phenoxybenzimidazole photolabels the N-terminal 63-103 amino acids of Haemonchus contortus beta-tubulin 1. Nare B, Lubega G, Prichard RK, Georges E.  J Biol Chem. 1996 Apr 12;271(15):8575-81.

Identification of a sister gene to P-glycoprotein. Childs S, Yeh RL, Georges E, Ling V.  Cancer Res. 1995 May 15;55(10):2029-34.

Benzimidazoles, potent anti-mitotic drugs: substrates for the P-glycoprotein transporter in multidrug-resistant cells. Nare B, Liu Z, Prichard RK, Georges E.  Biochem Pharmacol. 1994 Dec 16;48(12):2215-22.

Characterization of rhodamine 123 binding to P-glycoprotein in human multidrug-resistant cells. Nare B, Prichard RK, Georges E.  Mol Pharmacol. 1994 Jun;45(6):1145-52.

Effects of nonionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance. Zordan-Nudo T, Ling V, Liu Z, Georges E.  Cancer Res. 1993 Dec 15;53(24):5994-6000.

Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody. Georges E, Tsuruo T, Ling V.  J Biol Chem. 1993 Jan 25;268(3):1792-8.